BACKGROUND: Serotonin transporter promoter genotype appears to increase risk for depression in the context of stressful life events. However, the effects of this genotype on measures of stress sensitivity are poorly understood. Therefore, this study examined whether 5-HTTLPR genotype was associated with negative information processing biases in early childhood. METHOD: Thirty-nine unselected seven-year-old children completed a negative mood induction procedure and a Self-Referent Encoding Task designed to measure positive and negative schematic processing. Children were also genotyped for the 5-HTTLPR gene. (...) RESULTS: Children who were homozygous for the short allele of the 5-HTTLPR gene showed greater negative schematic processing following a negative mood prime than those with other genotypes. 5-HTTLPR genotype was not significantly associated with positive schematic processing. LIMITATIONS: The sample size for this study was small. We did not analyze more recently reported variants of the 5-HTTLPR long alleles. CONCLUSIONS: 5-HTTLPR genotype is associated with negative information processing styles following a negative mood prime in a non-clinical sample of young children. Such cognitive styles are thought to be activated in response to stressful life events, leading to depressive symptoms; thus, cognitive styles may index the "stress-sensitivity" conferred by this genotype. (shrink)

BackgroundAn increasing number of studies utilize intracranial electrophysiology in human subjects to advance basic neuroscience knowledge. However, the use of neurosurgical patients as human research subjects raises important ethical considerations, particularly regarding informed consent and undue influence, as well as subjects’ motivations for participation. Yet a thorough empirical examination of these issues in a participant population has been lacking. The present study therefore aimed to empirically investigate ethical concerns regarding informed consent and voluntariness in Parkinson’s disease patients undergoing deep brain (...) stimulator (DBS) placement who participated in an intraoperative neuroscience study.MethodsTwo semi-structured 30-minute interviews were conducted preoperatively and postoperatively via telephone. Interviews assessed participants’ motivations for participation in the parent intraoperative study, recall of information presented during the informed consent process, and participants’ postoperative reflections on the research study.ResultsTwenty-two participants (mean age = 60.9) completed preoperative interviews at a mean of 7.8 days following informed consent and a mean of 5.2 days prior to DBS surgery. Twenty participants completed postoperative interviews at a mean of 5 weeks following surgery. All participants cited altruism or advancing medical science as “very important” or “important” in their decision to participate in the study. Only 22.7% (n = 5) correctly recalled one of the two risks of the study. Correct recall of other aspects of the informed consent was poor (36.4% for study purpose; 50.0% for study protocol; 36.4% for study benefits). All correctly understood that the study would not confer a direct therapeutic benefit to them.ConclusionEven though research coordinators were properly trained and the informed consent was administered according to protocol, participants demonstrated poor retention of study information. While intraoperative studies that aim to advance neuroscience knowledge represent a unique opportunity to gain fundamental scientific knowledge, improved standards for the informed consent process can help facilitate their ethical implementation. (shrink)

This book casts new light on the traditional disagreement between those who hold that we cannot be morally responsible for our actions if they are causally determined, and those who deny this. Klein suggests that reflection on the relation between justice and deprivation offers a way out of this perplexity.

The relation between morality and religion has often been discussed. However, it is not always recognized that the relation varies greatly according to the variety of religions. I shall here be concerned solely with Christian theism in its traditional form. I take the latter to signify, essentially, belief in a morally perfect Creator who exists in the threefold form of Father, Son and Holy Spirit and who, in the person of the Son, became man in Christ for our salvation. I (...) thus exclude from consideration all non-theistic accounts of God or the Absolute. Also I shall consider, not simply bare theism of the kind that Christians share with Jews and Muslims, but also the distinctively Christian form of theism that is generated by distinctively Christian revelation. Many otherwise sound descriptions of the relation between morality and theism are defective because they fail to consider the distinctively Christian contribution to the theistic concept of God and of his relation to the world. (shrink)

Many writers often generalise about mysticism without a sufficiently close analysis of texts. Consequently the generalisations are often invalid. My present aim is to analyse one text and, in the light of this analysis, to offer some observations concerning mysticism in general and Christian mysticism in particular.

For over thirty years C. A. Campbell has made major contributions to both ethics and metaphysics. Since these do not correspond to the prevailing fashions in philosophy and theology they are in danger of being under-estimated, if not ignored. I hope to summarise and comment on them as impartially as possible. Inevitably I must be selective. In writing for this journal I have, naturally, chosen to stress those elements in Campbell's thought which are directly or indirectly relevant to religion. Even (...) so, there are many points which I have no space to develop. I shall be content if I say enough to indicate the importance of Campbell's writings for the study of the philosophically crucial topics to which they are devoted. (shrink)

Christianity affirms, with Judaism and Islam, that God is the omnipotent Creator of all things. But it diverges from them in also affirming that the Creator assumed a human nature in one figure of history, Jesus of Nazareth. Christ thus differs from other men in kind, not merely in degree; he is absolutely, not just relatively, unique. Admittedly many Christian theologians have held that the difference between Christ and other men is only one of degree. Yet the Church's traditional claim, (...) as expressed in the Chalcedonian Definition, is that Jesus was both creature and Creator, both fully man and fully God. (shrink)

First published in 1935, The Life and Writings of Giambattista Vico is a succinct biography of the Italian philosopher, Giambattista Vico. Carefully documented, the book comments on Vico's life as well as his oeuvre in a bid to extend his audience to the English-speaking population. From his early childhood to the influence of his writings after his death, the book provides a keen insight into the many facets of his philosophy. This book will be of interest to students of philosophy (...) and history. (shrink)

Business Ethics, the Environment &Responsibility, EarlyView.

Corporate social responsibility has been intensively discussed in business ethics literature, whereas the social responsibility of private consumers appears to be less researched. However, there is also a growing interest from business ethicists and other scholars in the field of consumer social responsibility. Nevertheless, previous discussions of ConSR reveal the need for a viable conceptual basis for understanding the social responsibility of consumers in an increasingly globalized market economy. Moreover, evolutionary aspects of human morality seem to have been neglected despite (...) the fact that private consumers are undoubtedly human beings. In addition to that, empirical studies suggest that many consumers believe themselves to be responsible but do not act according to their alleged values or attitudes. This raises the question of what deters them from doing so. Therefore, the contribution of this conceptual paper is threefold: we conceptualize ConSR in terms of a combination of a Max Weber-inspired approach with the social connection approach to shared responsibility proposed by Iris Marion Young; shed light on the previously neglected implications of an evolutionarily induced bounded morality for ConSR, and identify potential obstacles to socially responsible consumption, particularly against the backdrop of shared social responsibility and bounded morality. In this latter respect, the paper focuses specifically on the obstacles of low moral intensity, moral stupefaction, informational complexity, and the lack of perceived consumer effectiveness. In sum, the paper advances knowledge in the field of ConSR by using a transdisciplinary, literature-based approach. (shrink)

This handbook with exercises reveals the mathematical beauty of formalisms hitherto mostly used for software and hardware design and verification.

Poverty violates fundamental human values through its impact on individuals and on human environments, and it goes against the core values of democratic societies. Drawing on numerous scientific studies as well as his own experience witnessing the systematic poverty in his home country of South Africa, H. P. P. [Hennie] Lötter presents a holistic profile of poverty and its effects on human lives all the while accounting for the complexity of each individual case. He argues that shared ethical values must (...) guide the planning and distribution of aid and that our society must reevaluate our notions of justice and reimagine the role of the state in order to enable collective human responsibility for poverty’s successful eradication. (shrink)

This paper is a contribution toward developing a theory of expansions of semi-Heyting algebras. It grew out of an attempt to settle a conjecture we had made in 1987. Firstly, we unify and extend strikingly similar results of [ 48 ] and [ 50 ] to the (new) equational class DHMSH of dually hemimorphic semi-Heyting algebras, or to its subvariety BDQDSH of blended dual quasi-De Morgan semi-Heyting algebras, thus settling the conjecture. Secondly, we give a criterion for a unary expansion (...) of semi-Heyting algebras to be a discriminator variety and give an algorithm to produce discriminator varieties. We then apply the criterion to exhibit an increasing sequence of discriminator subvarieties of BDQDSH . We also use it to prove that the variety DQSSH of dually quasi-Stone semi- Heyting algebras is a discriminator variety. Thirdly, we investigate a binary expansion of semi-Heyting algebras, namely the variety DblSH of double semi-Heyting algebras by characterizing its simples, and use the characterization to present an increasing sequence of discriminator subvarieties of DblSH . Finally, we apply these results to give bases for “small” subvarieties of BDQDSH , DQSSH , and DblSH. (shrink)

The purpose of this paper is to resolve two paradoxes, which occur in quantum theory, by using the discussion of the theory of measurement presented in two earlier papers by the author [3], [4], [5]. The two paradoxes discussed will be the Schrödinger cat paradox and the Einstein, Podolski, Rosen paradox [2]. An introductory section will be included which summarizes the relevant results from the author's previous papers. Also a discussion will be made regarding the author's interpretation of the density (...) operator. (shrink)